Cultured Ovaries Were Successfully Implanted In Sterilized Mice

Cultured Ovaries Were Successfully Implanted In Sterilized Mice
Cultured Ovaries Were Successfully Implanted In Sterilized Mice

Video: Cultured Ovaries Were Successfully Implanted In Sterilized Mice

Video: 3D-printed ovary restores ovarian function in infertile mice 2022, December
Anonim

The technology for creating artificial organs has advanced quite well in recent years, and this gives hope that in the future it will be possible to replace any organ for a person. For example, we recently wrote about the creation of an artificial uterus. And now experts from Chicago have managed to grow and successfully transplant artificial ovaries into rodents.

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The ovaries were printed on special designs using a 3D bioprinter. Subsequently, the constructs were populated with cell culture. The experiment was conducted at the Feinberg School of Medicine, and was led by Dr. Teresa Woodroffe. The biggest challenge in making an artificial ovary has been to create a multi-layered porous structure that supports immature follicles and the hormone-producing cells around them. During the research, the team of experts found out that it is the follicle framework that ensures the efficiency and survival of the germ cells. Next, several mesh layers were printed and on their basis a skeleton was formed for an artificial ovary with a thickness of 2 millimeters.

Inside the scaffold were placed from 40 to 50 immature mouse follicles. These artificial ovaries were implanted into seven mice. All rodents managed to produce healthy offspring.

“We still have a lot of work to do, but demonstrating that the 3D ovaries we have created are functioning is a big breakthrough. It is very important that we have shown that this is feasible. It is quite possible that in the case of a successful completion of a series of experiments in a similar way, it will be possible to restore the reproductive function of patients who underwent removal of the ovaries due to diseases or after chemotherapy."

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